All rights reserved This article has been cited by other articles in PMC. Abstract In vitro fertilization, popularly referred to as IVF, has captured the attention of the public since its sensational introduction in Today assisted reproductive technology is available throughout most of the civilized world, and the practice is largely different from that used during the early days.
Live birth derived from oocyte spindle transfer to prevent mitochondrial disease Author information: The severity of clinical symptoms is often associated with the level of mtDNA mutation load or degree of heteroplasmy. Current clinical options to prevent transmission of mtDNA mutations to offspring are limited.
Experimental spindle transfer in metaphase II oocytes, also called mitochondrial replacement therapy, is a novel technology for preventing mtDNA transmission from oocytes to pre-implantation embryos.
A male euploid blastocyst wasobtained from the reconstituted oocytes, which had only a 5. Transfer of the embryo resulted in a pregnancy with delivery of a boy with neonatal mtDNA mutation load of 2. We report a case of a year-old nulligravida woman who had two failed IVF cycles characterized by all her embryos arresting at the two-cell stage and ultimately had pronuclear transfer using donor oocytes.
After her third IVF cycle, eight out of 12 patient oocytes and 12 out of 15 donor oocytes were fertilized. This report suggests that a potentially viable pregnancy with normal karyotype can be achieved through pronuclear transfer. Ongoing work to establish the efficacy and safety of pronuclear transfer will result in its use as an aid for human reproduction.
Recent data have shown that AGEs contribute to alterations in the ovarian microenvironment. This review presents and summarizes important clinical and experimental studies pertaining to the role of the AGE-RAGE system in obesity-related ovarian dysfunction.
It also discusses the role of the anti-inflammatory soluble Receptor for AGEs sRAGE in ovarian function and its changes in obesity and following unhealthy dietary habits. Thus data suggest that obesity-related alterations in the AGE-RAGE system and changes in circulating sRAGE level could potentially compromise ovarian response to controlled ovarian hyperstimulation and could adversely impact oocyte competence and ultimately fertility outcome.
Finally, there is a critical need to unveil the mechanistic actions of the AGE-RAGE system at the level of the oocyte and its surrounding granulosa and theca cells in order to better improve ovarian response to controlled ovarian hyperstimulation in obese women.
In a cohort study, patients aged 18—38 years undergoing their first IVF treatment at one US center were enrolled between February 1,and August 31, Ovarian response was categorized by the yield of MII oocytes low: The main outcome measure was cumulative live birth rate over a 6-month period.
The cumulative live birth rate was In conventional ovarian stimulation, live birth rate is not affected by the ovarian response. Whether oocytes produced from a low ovarian response are biologically more effective than oocytes obtained from a high ovarian response remains to be determined.
This phenomenon has been linked to an increase in oxidative stress and inflammatory markers.Published Papers. Live birth derived from oocyte spindle transfer to prevent mitochondrial disease.
although long-term follow-up of the child’s longitudinal development remains crucial. Poor ovarian response and retrieval of no oocytes following ovarian stimulation for in vitro fertilization (IVF) is a challenging problem for both the.
Free Term Paper on Reproductive Technology In Louise Brown became the first “test tube” baby to be born using in vitro fertilization (IVF). Her birth marked the advent of a rapidly advancing reproductive science, and it also became a testament to a changing concept of creation.
In vitro fertilisation (IVF) marks a great step forward in medical technology, and Australia is a leader in the field. IVF is now a popular procedure for couples who are infertile or are having trouble conceiving. In Vitro Fertilization is an assisted reproductive technology (ART) commonly referred to as IVF.
IVF is the process of fertilization by extracting eggs, retrieving a sperm sample, and then manually combining an egg and sperm in a laboratory dish. Category: essays research papers; Title: IVF - In Vitro Fertilization. My Account. IVF - In Vitro Fertilization.
IVF - In Vitro Fertilization Click the button above to view the complete essay, speech, term paper, or research paper. How to Cite this Page. MLA Citation: "IVF - In Vitro Fertilization.". Research papers on infertility can discuss many aspects of the issue that causes women and men a grave amount of anxiety and concern.
A medical research paper may take a holistic approach to examining the phenomenon of infertility, focusing on both the physical and emotional ramifications of .